Ray D. Strand
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 This is why magnesium deficiency is so underdiagnosed.
We all need at least 400-500 mg of magnesium in supplementation.
Vanadium is not a well-known mineral, but it is very important for the diabetic. It has been show to significantly increase insulin sensitivity when taken in supplementation. A diabetic needs to take 50-100 meg of vanadium in supplementation each day. |
Thomson Healthcare, Inc.
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 Magnesium homeostasis and clinical disorders of magnesium deficiency. Ann Pharmacother; 28:220-226. 1994
Melatonin description
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone produced by pinealocytes in the pineal gland during the dark hours of the day-night cycle. Serum levels of melatonin are very low during most of the day, and it has been labeled the "hormone of darkness. |
| Rude RK & Olerich M. Magnesium deficiency: possible role in osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int; 6(6):453-461. 1996
Rude RK. Physiology of magnesium metabolism and the important role of magnesium in potassium deficiency. Am J Cardiol; 63(14):31G-34G. 1989
Shattock MJ, Hearse DJ & Fry CH. The ionic basis of the anti-ischemic and anti-arrhythmic properties of magnesium in the heart. J Am Coll Nutr; 6:27-33. 1987
Song Y, He K, Levitan EB, et al. |
Herbert Ross, DC with Keri Brenner, L.Ac.
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 It activates cellular enzymes, plays a large role in nerve and muscle function, and helps regulate the body's acid-alkaline balance.43 magnesium deficiency can cause anxiety, muscle tremors, confusion, irritability, and pain. Processed food or foods cooked at high temperatures can be depleted of their magnesium content. Food sources: Tofu, nuts, seeds, sea vegetables, and leafy green vegetables, especially kale.
Supplements: Oral supplements of magnesium are absorbed well and will increase the measurable levels of this mineral inside red and white blood cells. |
Tori Hudson, N.D.
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 Otherwise, magnesium deficiency is rare. From the conventional scientific viewpoint, the main reason why magnesium is part of calcium supplements is that carbonates are constipating and magnesium has a laxative effect, and therefore the combination is usually better tolerated.
Even though calcium has received the most attention, alternative medicine views the importance of magnesium in skeletal metabolism and calcium regulation in a little bit different and perhaps broader context. Magnesium influences both matrix and mineral metabolism in bone. |
Carol Simontacchi
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 The scientific research performed on this mineral includes the following:
Severe magnesium deficiency is linked to a proinflammatory response and increases in oxidative stress, but studies verify that even milder magnesium deficiency increases inflammation.27
Low levels of calcium are caused by deficiencies of both magnesium and calcium. Consequently, magnesium supplementation is as important as calcium supplementation. Low bone mass is a common feature of this condition. This may lead to osteoporosis and possibly other bone-related disorders. |
Jonny Bowden, M.A., C.N.S.
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 Magnesium is absolutely essential for managing blood sugar, and magnesium deficiency correlates with insulin resistance. (Even the American Diabetes Association admits "strong associations . . . between magnesium deficiency and insulin resistance.") Many nutritionists estimate that as much as 80 percent of the population doesn't get enough magnesium (and it could easily be more). As an added benefit, magnesium supplementation can bring down LDL ("bad") cholesterol and
46-47 bring up HDL ("good") cholesterol, not exactly a bad "side effect"! |
Gabriel Cousens
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 Characteristic signs of Type-2 diabetes in children include: overweight, early stages of heart disease, magnesium deficiency, and insulin resistance. Chlorophyll through a plant-sourced diet is high in magnesium. Chlorophyll is an amazing food that is essential for humans, and at the center of every chlorophyll molecule is the element magnesium. Plant blood (chlorophyll) and human blood (hemoglobin) are not so different, as shown in Figure 21.
Magnesium is seventeen times as prevalent in the human heart as any other tissue in the body. Famous research scientist Dr. |
Stephen T. Sinatra, M.D.
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 Excessive loss of magnesium in the urine is the major cause of magnesium deficiency in diabetes, and low magnesium states have also been associated with insulin resistance. In addition, various bowel diseases and some medications impede the intestinal absorption of this mineral. For example, chronic use of H-2 receptor antagonists (like Tagamet and Zantac) to treat upper GI distress act as blockers when the body is trying to absorb dietary and supplemental magnesium. |
Jonny Bowden, Ph.D., C.N.S.
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 And though the National Institutes of Health tends to be more sanguine, pointing out that symptoms of real magnesium deficiency are rarely seen in the United States, it does point out that "there is concern about the prevalence of sub-optimal magnesium stores in the body," and that "dietary intake may not be high enough to promote an optimal magnesium status, which may be protective against disorders such as cardiovascular disease and immune dysfunction."
The excellent magnesium website www.mgwater. |
James Dowd and Diane Stafford
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 But we saw an unexpected increase in her PTH, which was 73; this pointed to protein and/or magnesium deficiency, which often accompanies vitamin D deficiency. So she boosted her protein intake and began supplementing her magnesium, too.
After six months on the Vitamin D Cure, she had scores of 0.5-30-35-40-7 and only five minutes of morning stiffness. Her weight was down to 158 and her vitamin D level rose to 54.
This shows how much weight a person can lose via vitamin D normalization and dietary modification. Sharon lost 22 pounds in six months, and she wasn't even on a diet! |
Ann M. Coulston and Carol J. Boushey
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 Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 21, 1024-1029.
Paolisso, G., Sgambato, S., Gambardella, A., Pizza, G., Tesauro, P., Varricchio, M., and D'Onofrio, F. (1992). Daily magnesium supplements improve glucose handling in elderly subjects. Am. J. Clin. Nutr. 55, 1161-1167. Kao, W. H. L., Folsom, A. R., Nieto, F. J., Mo, J.-P., Watson, R. S., and Brancati, F. L. (1999). Serum and dietary magnesium and the risk for type 2 diabetes mellitus: The Atherosclerosis Risk in Communities Study. Arch. Intern. Med. 159, 2151-2159. |
Andreas Moritz
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 Another finding emerged from the New York University Goldwater Memorial Hospital, which suggests that large doses of vitamin D can cause magnesium deficiency in the heart tissue and cause heart attacks.
Pregnant women are particularly at risk. Dietary intake of vitamin D has led to kidney calcification and severe mental retardation in their offspring. Children born to mothers, who take extra vitamin D in their diet, may develop a certain type of congenital heart disease called supravalvular aortic stenosis and show extreme deformations of facial bones. |
Stephen T. Sinatra, M.D.
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| The blood plasma level of magnesium was similar in both groups, but in patients with MVP the lymphocyte magnesium concentration was much lower than it was for healthy subjects, suggesting that magnesium deficiency may be part of the MVP syndrome.
This study also points up the important fact that blood measurement for magnesium might miss a deficiency in the cells of tissues, and while this cannot be ignored, it may all too often be overlooked by medical practitioners. I find that it's safest to err on the side of safety. |
Gabriel Cousens
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| Experimental work with magnesium deficiency showed that giving magnesium reduces tissue sensitivity to insulin. If the diet is depleted in potassium, it can also lead to insulin resistance at post-receptor sites.124 Zinc and chromium play a role in decreasing insulin resistance, as well as does vanadium. Biotin does appear to decrease insulin resistance according to research.123 Vitamin
E plays a role. About 600 mg was all that was needed to make a difference in insulin resistance.
Taurine and glutathione all seem to decrease insulin resistance. |
James Dowd and Diane Stafford
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| They are either consuming lots of calcium, or they have significant magnesium deficiency. Magnesium is required to produce PTH, so in severe magnesium depletion, PTH levels won't rise in response to very low vitamin D levels. Furthermore, these individuals may be relatively vitamin D-resistant because magnesium is required for vitamin D to function properly. Magnesium replacement in vitamin D deficiency through diet or supplementation is critical and is as important as replenishing calcium stores. |
Gabriel Cousens
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| Huerta has suggested that magnesium deficiency is related to Type-2 diabetes in obese children, who are more likely to have insulin resistance.99 This study was performed to see if obese children get enough magnesium in their diets and if a lack of magnesium can cause insulin resistance and thus Type-2 diabetes. Researchers found that 55 percent of obese children did not get enough magnesium from the foods they ate, compared with only 27 percent of lean children. The results showed that obese children got 14. |
Mark Sircus
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 It has been said that many sudden deaths following vaccination can be prevented by sufficient vitamin C and vitamin A reserves (or supplementation), but we should probably take a good look at magnesium deficiency as a crucial factor in sudden death.
In adults it has been seen how high levels of mercury in the heart becomes dangerous. Since deficient magnesium and high levels of mercury are related, childhood vaccines containing thi-merosal would be especially dangerous to administer in children deficient in magnesium.
According to Dr. |
| So they cannot get it through their neural circuits that magnesium deficiency, and not calcium deficiency plays a key role in osteoporosis.
Thus it is no surprise when we find more studies suggesting that high calcium intake had no preventive effect on alteration of bone metabolism in magnesium deficient rats10 and that not only severe but also moderate dietary restriction of magnesium results in qualitative changes in bones in rats."
The results from some of these studies may be surprising to some. |
| It is reasonable to suspect chronic latent magnesium deficiency in any patient with cardiovascular disease, diabetes mellitus, migraine, osteoporosis, or premenstrual syndrome, or risk factors for any of these conditions."24
As shown in the table on the next page, important nutrients disappear when whole wheat or other grains are refined. As this baker s dozen shows, the losses can be dramatic. For example, refined wheat flour has only 5% of the vitamin E as whole wheat flour. |
Joan Liebmann-Smith, Ph. D., and Jacqueline Nardi Egan
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 It can also signal magnesium deficiency. And finding normal noises annoying
SIGN OF THE TIMES
Beethoven not only started losing his hearing when he was 27 (apparently from otosclerosis) but also suffered from hypersensitivity to noise and tinnitus. By the time he was 50, he was totally deaf. Yet he continued to compose until his death a few years later. can be a sign of head injuries and whiplash, as well as depression and posttraumatic stress syndrome. |
Mark Sircus
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| Whole-wheat bread, for example, has twice as much magnesium as white bread because the magnesium-rich germ and bran are removed when white flour is processed. magnesium deficiency is more likely in those who eat a processed-food diet; in people who cook or boil all foods, especially vegetables, and in people who eat food grown in magnesium-deficient soil, where synthetic fertilizers containing no magnesium are often used. |
Gabriel Cousens
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| Other research has noted that magnesium deficiency resulted in impaired insulin secretion, and magnesium replacement restores insulin secretion. Dietary magnesium supplements (400 mg/day) were found to improve glucose tolerance in elderly individuals.145
In two new studies, in both men and women, those who consumed the most magnesium in their diet were least likely to develop Type-2 diabetes, according to a report in the January 2006 issue of Diabetes Care.U6 Until now, very few large studies have directly examined the long-term effects of dietary magnesium on diabetes. Dr. |
Gary Null and Amy McDonald
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 Sidney Baker emphasizes magnesium deficiency and yeast problems. He provides some historical background, starting with his presentation of a paper on magnesium at a conference years ago. "At this colloquium, there were magnesium experts from all over, mostly academic people, and mostly people who had jobs like running an intensive care unit or a cardiac care unit, or a department of immunology or obstetrics and gynecology. |
Jack Challem
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 Muscle spasms, charley horses, and restless legs syndrome are often signs of magnesium deficiency.
The mineral is essential for relaxing muscles. Your heart is a muscle, and it pumps blood by repeatedly contracting and relaxing. Its contraction depends in part on calcium, whereas relaxation requires magnesium. The same principle applies to other muscles in the body.
French researchers found that a combination of magnesium and vitamin B6 supplements reduced hyperactive symptoms in children. Those symptoms included poor attention, physical aggressiveness, twitchiness, and spasms. |
Mike Adams, the Health Ranger
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 For my wife, I actually designed a formula called Myo-Mag, which is mainly magnesium malate, but it has the coenzyme B vitamins, and if you look at the Kreb's cycle, she had a functional magnesium deficiency. She was not using magnesium -- even though she had plenty in her blood. Well, magnesium malate has this beautiful property; the malic acid actually kicks the Kreb's cycle into gear. Once you have the Kreb's cycle kicked into gear, then you need the magnesium to make the ATP or to use the ATP. Magnesium malate is wonderful. |
Jonny Bowden, Ph.D., C.N.S.
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| Up to 50 percent of patients who experience acute migraines have been shown to have a magnesium deficiency. This is actually not surprising because most adults in the United States—75 percent by some estimates—are deficient in this important mineral. The National Academy of Sciences recommends that all women over the age of thirty take 320 mg of magnesium daily, but half of them consume only 230 mg or even less. The academy suggests more for men: 420 mg, yet only half of men over thirty get more than 330 mg. |
Stephen T. Sinatra, M.D.
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| Researchers concluded that in the animal model, chronic magnesium deficiency leads to the development of severe hypertension, endothelial dysfunction, and free-radical stress.
These results were expanded in a 2004 study involving three groups of women of childbearing age (N=30). Investigators employed 3IP nuclear magnetic resonance spectroscopy to noninvasively measure the level of magnesium in the brain and skeletal muscle of twelve fasting nonpregnant women, eleven women in the third trimester of pregnancy, and seven women with pre-eclampsia. |
Dr. Steve Blake
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 Some alcohol withdrawal symptoms may be related to magnesium deficiency. In elderly populations absorption of magnesium may be lower. Also, magnesium losses in urine increase in older people. These factors, coupled with lower intakes, increase the risk of magnesium depletion in the elderly.
Summary for Magnesium
Main functions: strengthens bones, promotes muscle relaxation, and used to stabilize ATR Adequate Intake: for adults, 300 mg to 420 mg per day. Toxicity is possible from supplement use and may result in diarrhea.
Tolerable upper intake level is set at 350 mg for supplemental doses. |
Jonny Bowden, Ph.D., C.N.S.
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| The findings were so profound that the authors argued that the later development of osteoporosis may be due to a chronic magnesium deficiency. A second study done in 1998 suggested that magnesium consumed in
The Life Extension Foundation, an organization founded in 1980 that reports on the latest advances in life extension science, was first on the block to introduce a number of natural therapies to the public, including CoQIO and melatonin. In 1997, the foundation announced that SAMe "promises to be the most potent, multipurpose, anti-aging, anti-disease therapy we have ever introduced. |
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